Camden Town was opened by the Charing Cross, Euston & Hampstead Railway on 22 June 1907 with a 7 lever 'B' Style frame (frame number 81). The box was closed possibly in 1924.

A new Camden Town signalbox was opened by the London Electric Railway in 1924 fitted with a 43 lever 'B' frame (frame number 143). The box was closed on 23 July 1955, the frame was replaced by a push button desk and box was re-opened on 18 September 1955.